The Indians gave them a favorable treatment but the Puritans, who believed that they had a religious mission as a chosen people, began to show hostility against the Indians. The whites plundered and made attacks for games and corns without hesitation. With the first outbreak of an Indian attack against the whites in Virginia in 1622, which was an expression of anger against the harsh treatment and property loss that the Indian suffered from the whites, long-lasting conflicts between the white and Indians began.
It was simply impossible for the Indians to defeat the whites, who were armed with civilized weapons. Since then, Indians kept fighting against the whites who attempted to occupy their territory as shown by the Pontiac Rebellion led by Pontiac chief in 1763, the battle of Santee Sioux tribe in 1862, and the Apache guerrilla combat led by Geronimo. The Indians, however, were left only with numerous sacrifice and treaties calling for ceding the land. The numerous massacres including the killing of 800 Pequot Indian tribe in 1636 and the Sand Creek massacre which claims the lives of 600 Indians vividly show how atrocious the whites were in their attempt to control Indians.